Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

doi: 10.1124/jpet.116.237438

Figure Lengend Snippet: Workflow of the development and application of the PBPK kidney model for digoxin.

Article Snippet: All simulations presented herein were performed using the SimCYP population-based PBPK simulator software, version 14, release 1 (SimCYP, Sheffield, UK) ( ; ).

Techniques:

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

doi: 10.1124/jpet.116.237438

Figure Lengend Snippet: Mean simulated digoxin plasma concentration time profiles (intravenous administration of 1 mg digoxin) for intermediate PBPK models used during development of the mechanistic kidney model. CL R defined by a single input value (136.1 ml/ min) based on the literature analysis (orange line) and CL R simulated using the mechanistic kidney model, accounting for only glomerular filtration (purple line), glomerular filtration and reabsorption (turquoise line), or glomerular filtration, reabsorption, and active secretion (blue line).

Article Snippet: All simulations presented herein were performed using the SimCYP population-based PBPK simulator software, version 14, release 1 (SimCYP, Sheffield, UK) ( ; ).

Techniques: Concentration Assay, Filtration